PGT-SR

Pre-implantation genetic testing for chromosomal structural rearrangements (PGT-SR) tests for issues with chromosomes of your embryos that might cause developmental defects or recurrent miscarriage.

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What is PGT-SR?

Pre-implantation genetic testing for chromosomal structural rearrangements screens embryos created during IVF for structural changes in the chromosomes. It can also test for aneuploidy - where an embryo has an extra or missing chromosome.

Chromosomes are the packages of DNA within the cells of our body. Changes like deletions, duplications or inversions can cause miscarriage or developmental defects in children that are born. These changes can be inherited or happen spontaneously.

PGT-SR can be used if you’re at high risk of passing on a structural rearrangement to your child or have experienced multiple miscarriages caused by chromosomal abnormality.

TFP Oxford Fertility is one of the selected IVF units that provides NHS England-funded PGT-SR treatment.

How does PGT-SR work?

PGT-SR is carried out on embryos created during in vitro fertilisation (IVF).

A small sample of cells is taken from each embryo and sent off to an external lab in London where they are assessed for chromosomal abnormalities.

The embryos are frozen while we wait for the results of the biopsy. Any chromosomally normal embryos can be thawed ready for transfer or remain frozen until you're ready to use them.

Types of structural rearrangements

Inversion - One chromosome is affected where a segment is flipped upside down

Reciprocal translocation - Segments of genetic material are swapped between two chromosomes

Robertsonian translocation - Two chromosomes join together to create one long one, resulting in 45 chromosomes rather than 46

Structural rearrangements often result in extra or missing material in an embryo, called an unbalanced rearrangement. However, they can also be balanced. You can lead a perfectly healthy life with a balanced rearrangement, but your embryos are at risk of inheriting an unbalanced rearrangement when you conceive.

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Treatment

What is the PGT-SR process?

If you require pre-implantation genetic testing during IVF, we'll carefully take a sample of cells from each of the embryos created which is then sent to the Cooper Genomics Laboratory in London to be tested by expert embryologists.

A needle is used to capture a small sample of cells from an embryo

Biospy

During IVF, we grow your embryos for 5-6 days until they develop into a blastocyst. An embryologist will remove a small sample of cells from the blastocyst using a thin needle.

Embryo freezing

Following the biopsy, your embryos are frozen and safely stored in a cryopreservation chamber whilst you await the results of the genetic testing.

Freezing your eggs preserving your fertility

DNA testing

The DNA from the collected cells is tested to assess whether they are chromosomally normal.

This process takes around four weeks to complete.

Embryo transfer

After receiving the results of your pre-implantation genetic testing, any embryos that are not affected by genetic or chromosomal abnormalities are suitable for transfer. The highest quality embryo will be chosen so that you can continue your IVF cycle.

How much does PGT-SR cost?

If you choose to have PGT-SR as part of your IVF treatment, this will come with an additional charge. You'll find a breakdown below of the cost of your IVF cycle with PGT-SR.

*Any medication required throughout your treatment is a separate cost. ** All prices are subject to a regional variation.

What does live births per embryo transferred mean

IVF

£6,610

Includes egg retrieval and embryo transfer

PGT-SR

£1,810

Per embryo

Additional embryos

£500

Per embryo

Get in touch

Our Patient Support team is here to answer any questions you may have about PGT-SR and its pricing.

Fertility counselling

As part of your treatment plan, you'll have access to a specialised fertility counsellor. They can help you understand the impact of any chromosomal abnormalities you may carry and the risks associated with passing these onto a child. We’re here to reassure you, answer your questions, and give you the emotional support you need every step of the way.

Learn more