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Endometrial receptivity array test

The endometrial receptivity array (ERA) test is an optional procedure for individuals undergoing IVF treatment.

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What is the ERA test?

Endometrial receptivity array (ERA) testing is a genetic analysis to determine when it is best to carry out an embryo transfer to achieve a pregnancy.

The test allows the fertility doctor to analyse the endometrium, which is the inner lining of the womb that thickens during the menstrual cycle in preparation for implantation.

From this, they can determine whether the issues with the lining may be contributing to miscarriages or unsuccessful in vitro fertilisation (IVF) treatments.

However, it is important to note that there remains inconclusive evidence to support the use of ERA testing. Our current advice has been reviewed by Justin Chu, Medical Director at TFP Oxford Fertility.

The process

How does the ERA test work?

The ERA test is carried out during your menstrual cycle and there are different steps involved depending on your past fertility.

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Step 1 - Before the test

Before the ERA test, you may be prescribed medication to help enhance the lining of the womb and will be monitored through blood tests and ultrasounds. The medication can be given in tablet form.

Step 2 - At your ERA test

On the day you come into the clinic for your ERA test, your fertility doctor perform a biopsy of the endometrium (the inner lining of the womb) by inserting a small catheter into the womb cavity.

The result will determine whether the endometrium is receptive to an embryo implanting.

A needle is used to capture a small sample of cells from an embryo
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Cramping during and after the test

Patients undergoing an ERA test will likely experience some pain during the procedure and cramping after it is completed. To help with the discomfort, you can take paracetamol beforehand.

There is also a small risk of infection and bleeding, which will be discussed with you before your testing. Your consultant will be there to talk through any concerns you may have and provide you with the advice and guidance you need.

Step 3 - Embryo transfer

After your ERA test, you will undergo a personalised embryo transfer at the optimal time during the implantation window, to help increase the chance of conceiving. Your fertility doctor will discuss your possible embryo transfer dates with you.

Medical staff in scrubs prepare a patient on a gurney for egg retrieval, monitoring equipment in a hospital setting.

Who should have an ERA test?

An ERA test is recommended for individuals who have had failed embryo transfers or multiple unsuccessful IVF treatments.

However, your consultant will discuss whether an ERA test will be beneficial for your personal circumstances. Speak to your consultant if you have any queries about the ERA test.

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