Pre-implantation genetic testing for aneuploidy

Pre-implantation genetic testing for aneuploidy (PGT-A) checks embryos for abnormal numbers of chromosomes. This allows embryologists to select the best embryos for IVF treatment and reduce the chances of miscarriage.

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A needle is used to capture a small sample of cells from an embryo

What is PGT-A?

Pre-implantation genetic testing for aneuploidy (previously known as pre-implantation genetic screening or PGS) screens embryos created during IVF for abnormal numbers of chromosomes.

Chromosomes are the packages of DNA within the cells of our body. Normally, there are 46 chromosomes in each cell. When the number of chromosomes doesn’t equal 46, this is known as aneuploidy.

Aneuploidy in an embryo is one of the main causes of miscarriage or IVF failure, particularly in older patients. It also causes conditions such as Down’s Syndrome.

How does PGT-A work?

PGT-A is carried out on embryos created during in vitro fertilisation (IVF).

A small sample of cells is taken from each embryo and sent off to an external lab in London where they are assessed for chromosomal abnormalities.

The embryos are frozen while we wait for the results of the biopsy. Any embryos that contain a normal number of chromosomes can be thawed ready for transfer or remain frozen until you're ready to use them.

Who is PGT-A for?

We may recommend carrying out PGT-A on your embryos if:

You're an older patient (the risk of aneuploidy increases as you age)
You've had multiple previous miscarriages (recurrent miscarriages can be caused by chromosomal abnormalities)
You've had previous failed IVF cycles

Treatment

What is the PGT-A process?

If you require pre-implantation genetic testing during IVF, we'll carefully take a sample of cells from each of the embryos created which is then sent to the Cooper Genomics Laboratory in London to be tested by expert embryologists.

Biospy

During IVF, we grow your embryos for 5-6 days until they develop into a blastocyst. An embryologist will remove a small sample of cells from the blastocyst using a thin needle.

Embryo freezing

Following the biopsy, your embryos are frozen and safely stored in a cryopreservation chamber whilst you await the results of the genetic testing.

Freezing your eggs preserving your fertility

DNA testing

The DNA from the collected cells is tested to assess the number of chromosomes they contain.

This process takes around four weeks to complete.

Embryo transfer

After receiving the results of your pre-implantation genetic testing, any embryos that are not affected by genetic or chromosomal abnormalities are suitable for transfer. The highest quality embryo will be chosen so that you can continue your IVF cycle.

How much does PGT-A cost?

If you choose to have PGT-A as part of your IVF treatment, this will come with an additional charge. You'll find a breakdown below of the cost of your IVF cycle with PGT-A.

*Any medication required throughout your treatment is a separate cost. ** All prices are subject to a regional variation.

What does live births per embryo transferred mean

IVF

£6,610

Includes egg retrieval and embryo transfer

PGT-A

£870

Per embryo

Additional embryos

£500

Per embryo

Get in touch

Our Patient Support team is here to answer any questions you may have about PGT-A and its pricing.

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How successful is PGT-A?

Research indicates that PGT-A can reduce the time to pregnancy, as well as the risk of miscarriage, by avoiding the transfer for abnormal embryos.

It should be noted that the HFEA advises that PGT-A is a red flag rated add-on test as it does not increase the chance of pregnancy.

In some cases the test may show that no healthy embryos are available to continue your IVF cycle. Your consultant will talk you through the next steps in this instance.

Fertility counselling

As part of your treatment plan, you'll have access to a specialised fertility counsellor. They can help you decide what's right for you and what to expect from your treatment journey. We’re here to reassure you, answer your questions, and give you the emotional support you need every step of the way.

Learn more