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Treatment

Pre-implantation genetic testing for monogenic disorders

Pre-implantation genetic testing for monogenic disorders (PGT-M) can be used if you have or are a carrier of a genetic condition that you’re worried about passing onto your child. Monogenic disorders are genetic disorders caused by mutations in a single gene, for example, cystic fibrosis or Huntington's disease.

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An embryologist is assessing an embryo under a microscope

What is PGT-M?

Pre-implantation genetic testing for monogenic disorders (PGT-M) (previously known as pre-implantation genetic diagnosis) screens embryos created during IVF for specific conditions caused by single gene mutations, such as cystic fibrosis and Huntington's disease.

It can be used if you’re at high risk of passing on a genetic condition to your child.

TFP Oxford Fertility is one of the selected IVF units that provides NHS England-funded PGT-M treatment.

How does PGT-M work?

PGT-M is carried out on embryos created during in vitro fertilisation (IVF).

A small sample of cells is taken from each embryo and sent off to an external lab in London where they are assessed for chromosomal abnormalities.

The embryos are frozen while we wait for the results of the biopsy. Any embryos unaffected by the genetic condition can be thawed ready for transfer or remain frozen until you're ready to use them.

What does PGT-M test for?

PGT-M can test for over 1,700 genetic conditions approved by the HFEA including: Cystic fibrosis, Duchenne muscular dystrophy, haemophilia, Huntington's disease and sickle cell disease.

The HFEA lists the conditions that are approved for testing based on the risk of passing it on to a child and the seriousness of the symptoms.

If a condition is not currently on the list, we can apply to the HFEA for approval on your behalf as a licensed PGT-M provider.

Treatment

What is the PGT-M process?

If you require pre-implantation genetic testing during IVF, we'll carefully take a sample of cells from each of the embryos created which is then sent to the Cooper Genomics Laboratory in London to be tested by expert embryologists.

A needle is used to capture a small sample of cells from an embryo

Biospy

During IVF, we grow your embryos for 5-6 days until they develop into a blastocyst. An embryologist will remove a small sample of cells from the blastocyst using a thin needle.

Embryo freezing

Following the biopsy, your embryos are frozen and safely stored in a cryopreservation chamber whilst you await the results of the genetic testing.

Freezing your eggs preserving your fertility

DNA testing

The DNA from the collected cells is tested to see if they carry a specific genetic condition (PGT-M).

This process takes around four weeks to complete.

Embryo transfer

After receiving the results of your pre-implantation genetic testing, any embryos that are not affected by genetic or chromosomal abnormalities are suitable for transfer. The highest quality embryo will be chosen so that you can continue your IVF cycle.

How much does PGT-M cost?

If you choose to have PGT-M as part of your IVF treatment, this will come with an additional charge. You'll find a breakdown below of the cost of your IVF cycle with PGT-M.

*Any medication required throughout your treatment is a separate cost. ** All prices are subject to a regional variation.

What does live births per embryo transferred mean

IVF

£6,610

Includes egg retrieval and embryo transfer

PGT-M

£2,870

Per embryo

Additional embryos

£500

Per embryo

Get in touch

Our Patient Support team is here to answer any questions you may have about PGT-M and its pricing.

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How successful is PGT-M?

NHS data shows one in three cycles of IVF with PGT-M will result in a baby. At TFP Fertility, on average 53% of frozen embryo transfers that have undergone PGT-M result in a live birth.

However, there are many factors that can affect your fertility including age and other conditions.

In some cases the test may show that no healthy embryos are available to continue your IVF cycle. Your consultant will talk you through the next steps in this instance.

Fertility counselling

As part of your treatment plan, you'll have access to a specialised fertility counsellor. They can help you decide what's right for you and what to expect from your treatment journey. We’re here to reassure you, answer your questions, and give you the emotional support you need every step of the way.

Learn more